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Methadone contains methadone, a mu-agonist opioid with an abuse liability similar to other opioid agonists and is a Schedule II controlled substance. Methadone and other opioids used in analgesia have the potential for being abused and are subject to criminal diversion.
Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.
Teratogenic Effects. Pregnancy Category Kohlenstoff – There are no controlled studies of methadone use rein pregnant women that can Beryllium used to establish safety. However, an expert Bericht of published data on experiences with methadone use during pregnancy by the Teratogen Information Organisation (TERIS) concluded that maternal use of methadone during pregnancy as parte of a supervised, therapeutic regimen is unlikely to pose a substantial teratogenic risk (quantity and quality of data assessed as “limited to fair”). However, the data are insufficient to state that there is no risk (TERIS, belastung reviewed October, 2002). Pregnant women involved hinein methadone maintenance programs have been reported to have significantly improved prenatal care leading to significantly reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs.
Abuse of methadone poses a risk of overdose and death. This risk is increased with concurrent abuse of methadone with alcohol and other substances. In addition, parenteral drug abuse is commonly associated with transmission of infectious diseases such as hepatitis and HIV.
For patients preferring a brief course of stabilization followed by a period of medically supervised withdrawal, it is generally recommended that the patient be titrated to a total daily dose of about 40 mg rein divided doses to achieve an adequate stabilizing level. Stabilization can be continued for 2 to 3 days, after which the dose of methadone should Beryllium gradually decreased.
Patients developing QT prolongation while on methadone treatment should Beryllium evaluated for the presence of modifiable Methadontabletten online kaufen risk factors, such as concomitant medications with cardiac effects, drugs which might cause electrolyte abnormalities, and drugs which might act as inhibitors of methadone metabolism. For use of methadone to treat pain, the risk of QT prolongation and development of dysrhythmias should be weighed against the benefit of adequate pain management and the availability of alternative therapies.
Methadone belongs to a class of drugs called opioids (narcotics). A class of drugs is a group of medications that work hinein a similar way. These drugs are often used to treat similar conditions.
Methadone is also available as the Großbrand-name drug Methadose, which comes hinein an oral soluble tablet.
Several studies have suggested that infants born to narcotic-addicted women treated with methadone during all or part of pregnancy have been found to have decreased fetal growth with reduced birth weight, length, and/or head circumference compared to controls.
Methadone hydrochloride tablets can cause your blood pressure to drop. This can make you feel dizzy if you get up too fast from sitting or lying down.
Methadone-maintained patients beginning treatment with CYP3A4 inducers should Beryllium monitored for evidence of withdrawal effects and methadone dose should Beryllium adjusted accordingly.
Deaths have been reported during conversion to methadone from chronic, high-dose treatment with other opioid agonists and during initiation of methadone treatment of addiction hinein subjects previously abusing high doses of other agonists.
Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly during the initial dosing period.
Initial doses should not be determined by previous treatment episodes or dollars spent qua day on illicit drug use.